PI: Andrew M. Scharenberg, MD
Location: UW Immunology, Seattle Children’s
New technologies for gene editing
Our laboratory focuses on gene editing technology and translational applications in adoptive T-cell immunotherapies and hematopoietic stem cell gene therapy. Our lab has a particular interest in the development of new technologies to increase the efficiency and safety of gene editing. Ongoing work includes new approaches for nuclease expression in primary cell types, alternative approaches for provision of recombination templates, and methods for manipulation of the DNA repair machinery to promote recombination-based genome editing. We also collaborate with Dr. Michael Jensen’s laboratory on applications of gene editing for adoptive immunotherapy for oncology applications, and are particularly interested in protein design problems related to control of cell activation, proliferation, and effector functions.