The Institute for Protein Design is looking for talented individuals to join its growing team. Persons who enjoy working in a dynamic team environment should contact us to learn more about potential job opportunities.
Baker Lab: Lab Manager
The Baker Laboratory at the University of Washington’s Department of Biochemistry, Institute for Protein Design currently has an outstanding opportunity for a Research Scientist/Engineer 2 to serve as Laboratory Manger.
This individual will serve as Laboratory Manager for a 50 –person laboratory of postdoctoral fellows, graduate students and undergraduate student helpers. This person will manage the Baker Laboratory scientific supply inventory and ordering, and assist in monitoring laboratory usage and equipment maintenance, and oversee the work of the undergraduate support aids, with assigned duty support from Baker laboratory postdoctoral fellows and graduate students. This role also involves managing undergraduates who support the lab in glassware washing and standard solution preparation. This role also involves orientation of new lab members, providing educational information on lab practice, professional conduct and chemical safety. Strong organizational, leadership and communication skills are required.
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Gu Lab: Postdoctoral Fellow
Postdoctoral positions in protein barcoding and in situ DNA sequencing technologies for protein design at the University of Washington
Openings: Closed. Please check back at a later time.
The laboratory of Dr. Liangcai Gu in the Department of Biochemistry and the Institute for Protein Design (IPD) at the University of Washington School of Medicine invites applications for up to three postdoctoral positions in image processing for in situ polony sequencing, next-generation sequencing for immune profiling, and protein barcoding technologies. The positions are available immediately.
We use quantitative protein interaction profiling to understand molecular recognition and guide computational protein design. To fundamentally improve quality and cost-effectiveness of high-throughput protein analysis, we develop protein interaction sequencing technologies by coupling ‘protein barcoding’ techniques to in situ barcode (or polony) sequencing, a powerful extension of next-generation sequencing technologies. Proteins are barcoded by attaching them to a barcoding DNA via enzymatic conjugation or protein displays. In situ polony sequencing can directly measure protein interactions in massively parallel at a single-molecule or single-cell level. An example of protein interaction sequencing is a single-molecular-interaction sequencing (SMI-seq) technology we recently developed (Nature, 2014, 515, 554–557) for ‘library-by-library’ or ‘all-by-all’ interaction profiling. We apply SMI-seq and others to measure natural or synthetic protein interactions to explore the druggability of human protein interactomes and to develop molecule sensors, vaccines and therapeutic T cells. We collaborate with world-class laboratories on protein design and sequencing technologies at the University of Washington and other institutes. Postdocs will work in a highly interdisciplinary and collaborative research environment and can be under a joint supervision of Dr. Gu and another advisor(s) with complementary expertise and research interests. Postdocs jointly trained in IPD and any Seattle-area research institute (including the University of Washington) are also eligible to apply for a Washington Research Foundation (WRF)‒IPD Innovation Fellowship (http://www.ipd.uw.edu/fellows/).
Applicants should have a Ph.D. degree (or equivalent) in related fields including, but not limited to biochemistry, bioengineering, bioinformatics, biophysics, computer science and chemistry. Highly desirable backgrounds/skills include i) phage, ribosome, mRNA or other protein display techniques for protein engineering; ii) high-throughput image processing and analysis; iii) next-generation sequencing of immune repertoire; iv) strong programming skills in scripting language (Python or Perl), statistical and computing language (R or MATLAB), and/or programing language (C/C++ /Java).
Applicants should have a strong publication record, good spoken and written communication skills. Interested applicants should send i) a cover letter briefly describing your previous experience and your future research interests/plans, ii) a curriculum vitae, and iii) contact information of three references to Dr. Liangcai Gu (email@example.com).
The University of Washington is an affirmative action and equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran or disabled status, or genetic information.
Please apply through one of the sites below: