De novo design of small beta barrel proteins
The de novo design of small proteins with beta-barrel topologies has been a challenge for computational design due to the complexity inherent in these folds. In a new study appearing in PNAS, a team led by Baker Lab research scientist David E. Kim describes the successful design and characterization of four different classes of small […]
Degreaser: Improving protein secretion
King Lab postdoctoral scholars John Wang and Alena Khmelinskaia have developed a new tool for identifying and removing hidden transmembrane sequences that hinder protein secretion.
EMERALD: Automatically locate ligands in cyroEM maps
Under ideal conditions, cryo-electron microscopy can be used to determine protein structures at near-atomic resolution. But conditions are not always perfect. To help researchers make use of medium-resolution cryo-electron density maps, scientists in the DiMaio Lab have developed EMERALD, which is a new software tool that can accurately and automatically produce deposition-ready small molecule models […]
Lazarovits and Ueda receive WRF translational funding
Washington Research Foundation (WRF) has awarded a $498,804 technology commercialization grant to Institute for Protein Design researchers Drs. James Lazarovits and George Ueda. The funding will enable Lazarovits and Ueda to further develop their “plug and play” Antibody Cage (AbC) Platform, which converts antibodies into new structures that uniquely bind multiple targets to improve treatment […]
Machine learning generates custom enzymes
Today we report in Nature the computational design of highly efficient enzymes unlike any found in nature. Laboratory testing confirms that the new light-emitting enzymes can recognize specific chemical substrates and catalyze the emission of photons very efficiently.
“Scientists use new A.I. tech to fight diseases”
NBC reports on how our scientists are harnessing artificial intelligence to improve how proteins for medicines and vaccines are developed.
Frontiers of Knowledge Award goes to David Baker, Demis Hassabis and John Jumper
The 15th BBVA Foundation Frontiers of Knowledge Award in Biology and Biomedicine has gone to David Baker, Demis Hassabis and John Jumper “for their contributions to the use of artificial intelligence for the accurate prediction of the three-dimensional structure of proteins.” From the BBVA Foundation: Baker – a Professor of Biochemistry at the University of […]
“A.I. Turns Its Artistry to Creating New Human Proteins”
The New York TImes has reported on how, Inspired by digital image generators like DALL-E, our scientists are building artificial intelligences that can fight cancer, flu and COVID-19.
Establishing our first international translational research project
From our partners at the BioInnovation Institute: BioInnovation Institute (BII), an international enterprise foundation with a non-profit objective incubating and accelerating world-class life science research, announces today that it has accepted a new project into its Bio Studio program. Based on recent breakthroughs in Artificial Intelligence (AI) and protein design, the project is creating a […]
David Baker to present at the NIH Director’s Lecture Series
David Baker presented at the NIH Director’s Wednesday Afternoon Lecture Series on December 14, 2022. From the National Institutes of Health: The NIH Director’s Wednesday Afternoon Lecture Series, colloquially known as WALS, is the highest-profile lecture program at the NIH. Traditionally, lectures have occurred on most Wednesdays from September through June from 3:00 to 4:00 […]