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Lynda Stuart appointed Executive Director of the Institute for Protein Design
The Institute for Protein Design (IPD) is pleased to announce the appointment of Lynda Stuart, MD, PhD, as its new Executive Director. Dr. Stuart, an accomplished immunologist and former Deputy Director at the Bill & Melinda Gates Foundation, assumes her new role on May 1. Dr. Stuart is a physician, scientist, and advocate for healthcare […]
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Undergrad researcher Hannah Han is in the Husky 100
The University of Washington today announced that IPD Undergraduate Researcher Hannah Han is among the 2023 Husky 100. Each year, the Husky 100 recognizes 100 undergraduate and graduate students from the UW Bothell, Seattle, and Tacoma campuses in all areas of study who are making the most of their time at the University of Washington. […]
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Top-down design of protein architectures with reinforcement learning
Today we report in Science [PDF] the successful application of reinforcement learning to a challenge in protein design. This research is a milestone in the use of artificial intelligence for science, and the potential applications are vast, from developing more effective cancer treatments to new biodegradable textiles. A team led by scientists in the Baker […]
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“Generative AI is dreaming up new proteins”
Chemical & Engineering News reports that it’s time for chatbots and image generation to move over. AI-powered protein design is having a moment.
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Abigail Burtner named a UW Goldwater Scholar
Five University of Washington undergraduates have been honored as Goldwater Scholars by the Goldwater Foundation, marking 2023 as the first time five students from the UW were named in a single year. The Goldwater Foundation awards undergraduate scholarships to students who show exceptional academic promise pursuing research careers in the natural sciences, mathematics and engineering. The […]
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Design of binders for disordered targets
Today we report in Nature the design of proteins that recognize and bind to the so-called “intrinsically disordered regions” of proteins and peptides. The body produces such disordered molecules naturally, but many have been linked to health disorders, including myeloma and other cancers. “Disordered proteins play important roles in biology. By designing new proteins that […]
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RF Diffusion now free and open source
Today we are making RF Diffusion, our artificial intelligence (AI) program that can generate novel proteins with potential applications in medicine, vaccines, and advanced materials, free for both non-profit and for-profit use under a governed license. The software, which has been tested in the lab, is much faster and more capable than prior protein design […]
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De novo design of small beta barrel proteins
The de novo design of small proteins with beta-barrel topologies has been a challenge for computational design due to the complexity inherent in these folds. In a new study appearing in PNAS, a team led by Baker Lab research scientist David E. Kim describes the successful design and characterization of four different classes of small […]
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Degreaser: Improving protein secretion
King Lab postdoctoral scholars John Wang and Alena Khmelinskaia have developed a new tool for identifying and removing hidden transmembrane sequences that hinder protein secretion.
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EMERALD: Automatically locate ligands in cyroEM maps
Under ideal conditions, cryo-electron microscopy can be used to determine protein structures at near-atomic resolution. But conditions are not always perfect. To help researchers make use of medium-resolution cryo-electron density maps, scientists in the DiMaio Lab have developed EMERALD, which is a new software tool that can accurately and automatically produce deposition-ready small molecule models […]
