Tag: Review

  • Hyper-stable Designed Peptides and the Coming of Age for De Novo Protein Design

    Hyper-stable Designed Peptides and the Coming of Age for De Novo Protein Design

    Small constrained peptides combine the stability of small molecule drugs with the selectivity and potency of antibody-based therapeutics. However, peptide-based therapeutics have largely remained underexplored due to the limited diversity of naturally occurring peptide scaffolds, and a lack of methods to design them rationally.  New computational design and wet lab methods developed at the Institute for…