Latest posts
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Flu Binder Paper Debuts in PLOS Pathogens
Today at 11am, the paper titled “A Computationally Designed Hemagglutinin Stem-Binding Protein Provides In Vivo Protection from Influenza Independent of a Host Immune Response” was published to the PLOS Pathogen website. This paper was contributed to by several IPD members, including Aaron Chevalier, Jorgen Nelson, Lance Stewart, Lauren Carter, and David…
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Dr. Ingrid Swanson Pultz on UW Medicine Pulse
Recently, UW Medicine Pulse released a podcast featuring none other than our very own Ingrid Swanson Pultz! They talked to her about KumaMax and how it would help those with Celiac’s disease. Go here to see their post on it and listen to the podcast! Would you like to contribute…
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Big moves in protein structure prediction and design
[envira-gallery id=”3246″] Custom design with atomic level accuracy enables researchers to craft a whole new world of proteins Naturally occurring proteins are the nanoscale machines that carry out essentially all of the critical functions in living things. While it has been known for over 40 years that the sequence of…
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CASP3-11 Results Published in E-Life
In the early 1990s, researchers in the field of protein structure prediction were challenged by the problem of how to impartially judge the accuracy of prediction algorithms. This realization led the protein structure prediction the community to start the Critical Assessment of protein Structure Prediction (CASP), a community-wide, worldwide experiment…
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September IPD News Roundup
RESEARCH IPD Translational Investigator, Dr. Ingrid Pultz, published a paper in JACS this month titled ‘Engineering of Kuma030: A Gliadin Peptidase That Rapidly Degrades Immunogenic Gliadin Peptides in Gastric Conditions‘. Using Rosetta to redesign the active site of the gliadin protease KumaMax – an enzyme computationally designed to break down gluten in the…
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Cyrus hires new EVP of Sales
Cyrus Biotechnology, the first company spinout from the IPD’s Translational Investigator Program, welcomes their new EVP of Sales, Rosario Caltabiano. Follow the link to the Cyrus website to learn more: http://cyrusbio.com/2015/10/01/cyrus-welcomes-evp-rosario-caltabiano/
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August IPD News Roundup
RESEARCH Following the groundbreaking 2014 Nature paper describing the development of a computational method to design multi-component coassembling protein nanoparticles, comes a publication in Protein Science from Baker lab graduate student Jacob Bale and collaborators. Titled “Structure of a designed tetrahedral protein assembly variant engineered to have improved soluble expression“, the paper reports a…
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July IPD News Roundup
RESEARCH In an article out in Structure, Baker lab postdoc Dr. Hahnbeom Park in collaboration with IPD Assistant Professor Frank DiMaio investigate the origin of protein structure refinement from structural averaging at the residue level. Structure refinement has long been a challenge in the field of protein structure prediction and…
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June IPD News Roundup
RESEARCH A new Science paper is out from Dr. David Baker and IPD collaborator Dr. Tamir Gonen (HHMI Janelia Campus) titled Design of ordered two-dimensional arrays mediated by noncovalent protein-protein interfaces. Graduate student Shane Gonen and Dr. Frank DiMaio describe a new computational approach to design two-dimensional protein arrays with a…
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New Science paper: Designed 2-D protein arrays
A new Science paper is out from IPD faculty Dr. David Baker titled Design of ordered two-dimensional arrays mediated by noncovalent protein-protein interfaces. Read the abstract below and the article at the link: http://www.sciencemag.org/content/348/6241/1365 We describe a general approach to designing two-dimensional (2D) protein arrays mediated by noncovalent protein-protein interfaces. Protein homo-oligomers are…