• COVID-19 vaccine with IPD nanoparticles wins full approval abroad

    COVID-19 vaccine with IPD nanoparticles wins full approval abroad

    • Clinical testing found the vaccine outperforms Oxford/AstraZeneca’s • The protein-based vaccine, now called SKYCovione, does not require deep freezing • University of Washington to waive royalty fees for the duration of the pandemic • South Korea to purchase 10 million doses for domestic use A vaccine for COVID-19 developed at the University of Washington […]

  • AWS gift supports protein structure prediction and design

    AWS gift supports protein structure prediction and design

    Amazon Web Services (AWS), a leading cloud computing platform, is donating server time to the Institute for Protein Design to accelerate research in protein structure prediction and design. Computing credits valued at over $1M will be used to train optimized versions of RoseTTAFold for higher accuracy. The research will also support the ongoing development of […]

  • Anindya Roy wins Go-To-Market Award for drug development

    Anindya Roy wins Go-To-Market Award for drug development

    The Washington Entrepreneurial Research Evaluation and Commercialization Hub (WE-REACH) is pleased to announce a product concept award for Dr. Anindya Roy and his team at the UW Medicine Institute for Protein Design, including Drs. Jake Kraft and Hua Bai. They are developing a novel binder protein in an aerosolized delivery system to treat idiopathic pulmonary […]

  • COVID-19 vaccine with IPD nanoparticles seeks full approval

    COVID-19 vaccine with IPD nanoparticles seeks full approval

    A COVID-19 vaccine developed at the University of Washington School of Medicine has proven safe and effective in late-stage clinical testing. SK bioscience, the company leading the vaccine’s clinical development abroad, is seeking full approval for its use in South Korea and beyond. If approved by regulators, the vaccine will be made available through COVAX, […]

  • Custom biosensors for detecting coronavirus antibodies in blood

    Custom biosensors for detecting coronavirus antibodies in blood

    Today we report in Nature Biotechnology the design of custom protein-based biosensors that can detect coronavirus-neutralizing antibodies in blood. This research, which builds on prior sensor design technology developed in the Baker lab, was led by Baker lab postdoctoral scholars Jason Zhang, PhD, and Hsien-Wei (Andy) Yeh, PhD. From Behind the Paper: [W]e utilized the […]

  • Rotory proteins designed from scratch

    Rotory proteins designed from scratch

    Today we report in Science the design of rotary devices made from custom proteins. These microscopic “axles” and “rotors” come together to form spinning assemblies, rather than being locked in just one orientation. Such mechanical coupling is a key feature of any machine. The new axle-rotor devices — which are each about a billion times […]

  • Protein drugs designed from the ground up

    Protein drugs designed from the ground up

    Today we report in Nature a new method for generating protein drugs. Using Rosetta-based design, an international team designed molecules that can target important proteins in the body, such as the insulin receptor, as well as proteins on the surface of viruses. This solves a long-standing challenge in drug development and may lead to new treatments for […]

  • Diverse protein assemblies by (negative) design

    Diverse protein assemblies by (negative) design

    A new approach for creating custom protein complexes yields asymmetric assemblies with interchangeable parts. Today we report in Science the design of new protein assemblies made from modular parts. These complexes — which adopt linear, branching, or closed-loop architectures — contain up to six unique proteins, each of which remains folded and soluble in the absence […]

  • Breakthrough of the Year

    Breakthrough of the Year

    The journal Science has selected artificial intelligence algorithms that predict the three-dimensional shapes of proteins — as well as the blizzard of protein structures they have revealed — as their 2021 Breakthrough of the Year. We are honored to have our work in this field recognized alongside that of the company DeepMind. As David Baker told […]

  • Deep learning dreams up new protein structures

    Deep learning dreams up new protein structures

    Just as convincing images of cats can be created using artificial intelligence, new proteins can now be made using similar tools. In a new report in Nature, we describe the development of a neural network that “hallucinates” proteins with new, stable structures. “For this project, we made up completely random protein sequences and introduced mutations […]