Employment

Research Scientist 3 – Nanoparticles

The Research Scientist 3 – Nanoparticle Production Core will perform professional work in support of scientific research in protein production and biophysical characterization of computationally designed proteins. The research activities involve leading production of nanoparticle vaccine candidates and nanoparticle components at the IPD.

RESPONSIBILITIES:
In this role, 80% of effort will be dedicated to the production and management of ongoing nanoparticle projects. The remaining 20% of the effort will be dedicated to training and mentoring of direct and indirect reports.

1. Collaboration with numerous researchers at the IPD in the production of designed self-assembling protein nanoparticles and their components, including preparation of detailed Certificates of Testing and/or reports.

2. Participates in complex projects with uncertain outcomes requiring analysis from multiple perspectives.

3. Uses expert knowledge and judgment to develop new methods and techniques for obtaining solutions EM characterization of de novo designed proteins and protein nanomaterials. 

4. Manage the activities of two (2) entry-level technical support staff along with a minimum of one (1) part-time undergraduate support person.

5. Directs projects with undefined timelines and uncertain outcomes requiring analysis from multiple perspectives.

6. Uses expert knowledge and judgment to develop new methods and techniques for obtaining solutions.

REQUIREMENTS:
Bachelor’s degree in Protein Biochemistry or Bioengineering + 3 or more years of experience in a related field to include: experience in protein expression, purification, and characterization; and experience in hands nanoparticle production and characterization.
• This position requires that the Research Scientist 3 be capable of selecting and applying standardized scientific procedures and techniques to assignments of moderate complexity, involving potentially conflicting design requirements.
• Technical proficiency, scientific creativity, collaborative ability as well as independent thought.
• Recognized as a resource for others to use in dealing with protein expression, purification, and characterization.
• In-depth understanding of organizational structure both within and outside the work unit, including the role of each position in the group and in other groups.
• Ability to develop innovative processes to achieve goals. Directs others to develop essential tasks. Reviews work activities to determine where new information could improve processes or move projects forward.
• Ability to select and apply standardized scientific procedures and techniques to assignments of moderate complexity, involving potentially conflicting design requirements.

Equivalent education/experience will substitute for all minimum qualifications except when there are legal requirements, such as a license/certification/registration.

DESIRED EXPERIENCE
The ideal Research Scientist 3 in Nanoparticle Production Core will be someone who (i) selects and applies standardized scientific procedures and techniques to assignments of moderate complexity, (ii) continually learns and develops methods, (iii) can manage individual research projects that they own, (iv) knows or can learn how to operate current purification and characterization instruments at the IPD, (v) can accurately process negative stain EM imaging data, (vi) and has a deep desire to train others as a mentor in all of these areas, so that others within the IPD can successfully manufacture nanoparticles following efficient standard operating procedures.
• Expertise in protein structural characterization by negative stain EM methods.
• Expertise in computational protein design using Rosetta
• Familiarity in vaccine efficacy study design, in order to contribute to the design of immunogenicity and
efficacy studies for vaccine candidates.
• Familiarity with GLP practices, including Certificates of Testing and batch records.

Application Process:
The application process for UW positions may include completion of a variety of online assessments to obtain additional information that will be used in the evaluation process.  These assessments may include Workforce Authorization, Cover Letter and/or others.  Any assessments that you need to complete will appear on your screen as soon as you select “Apply to this position”. Once you begin an assessment, it must be completed at that time; if you do not complete the assessment you will be prompted to do so the next time you access your “My Jobs” page. If you select to take it later, it will appear on your “My Jobs” page to take when you are ready. Please note that your application will not be reviewed, and you will not be considered for this position until all required assessments have been completed.

Applicants considered for this position will be required to disclose if they are the subject of any substantiated findings or current investigations related to sexual misconduct at their current employment and past employment. Disclosure is required under Washington state law.

Committed to attracting and retaining a diverse staff, the University of Washington will honor your experiences, perspectives and unique identity. Together, our community strives to create and maintain working and learning environments that are inclusive, equitable and welcoming.

CLICK HERE TO APPLY

Preclinical Research Scientist 3

The UW Institute for Protein Design is seeking to hire a Preclinical Research Scientist (Research Scientist/Engineer 3) to serve as the leader for in vivo small animal studies. This Preclinical Research Scientist will provide a core competency in in vivo animal models at the IPD, thereby fulfilling a growing demand for the evaluation of the functional characteristics of designed proteins in vivo. The Preclinical Research Scientist will be assigned work under general guidance and receive instruction on specific assignment objectives, complex features, and possible solutions. Guidance on unusual problems will be provided to the Preclinical Research Scientist by IPD Faculty, other UW Faculty, or animal facilities employees who are experts in animal models, and work shall be reviewed for application of sound professional judgment.

The Preclinical Research Scientist will serve as the lead scientist in the IPD’s In Vivo Core lab, having oversight of collaborative preclinical in vivo research using small animal models to assess biodistribution, pharmacokinetics, safety, efficacy, and immunogenicity of computationally designed proteins and immunogens. This position will perform professional work in support of scientific research evaluating the characteristics of designed proteins in vivo in common small animal models.

RESPONSIBILITIES:
• In this role, ~60% of the effort will be dedicated to performing preclinical research evaluating the characteristics of designed proteins in vivo in common small animal models.
• Another ~30% of effort will be dedicated to coordinating study designs and communicating the results and interpretations of each study with a number of internal collaborators at the IPD and in some cases external collaborators at other institutions.
• The remaining ~10% of effort will be dedicated to continuous improvement of the In Vivo Core lab operations and standard operating procedures and interfacing with UW veterinary service personnel and the Office of Animal Welfare (OAW).

REQUIREMENTS:
• Master’s Degree in Biochemistry + 3 or more years of experience in related field.
• The ideal Preclinical Research Scientist candidate will be someone who (i) selects and applies standardized scientific procedures and techniques to assignments of moderate to high complexity, involving potentially conflicting design requirements, (ii) continually learns and develops new in vivo methods and study designs, (iii) can manage individual research projects that they own, (iv) can provide timely and professional scientific services to a number of internal collaborators on several different projects, (v) can perform in vivo studies of novel molecules in a safe and humane manner, (vi) and enjoys interacting with other scientists in a highly collaborative and fast-paced work environment.

Equivalent education/experience will substitute for all minimum qualifications except when there are legal requirements, such as a license/certification/registration.

DESIRED EXPERIENCE
• Excellent knowledge of small animal biology and immunology and experience in conducting exploratory research using xenograft or syngeneic tumor models and humanized mouse models is highly preferred.
• Significant hands-on experience with mouse and rat models and their application in evaluating anti-cancer therapies, immunotherapeutics, or vaccines is highly desired.
• Experience with immunological readouts and their translation into early clinical trials is highly desirable.
• Familiarity with drug discovery is a plus.
• The ability to flourish in a highly matrixed organization and work well within multidisciplinary teams is desirable.

As a UW employee, you will enjoy generous benefits and work/life programs. For detailed information on Benefits for this position, click here.

Application Process:
The application process for UW positions may include completion of a variety of online assessments to obtain additional information that will be used in the evaluation process.  These assessments may include Workforce Authorization, Cover Letter and/or others.  Any assessments that you need to complete will appear on your screen as soon as you select “Apply to this position”. Once you begin an assessment, it must be completed at that time; if you do not complete the assessment you will be prompted to do so the next time you access your “My Jobs” page. If you select to take it later, it will appear on your “My Jobs” page to take when you are ready. Please note that your application will not be reviewed, and you will not be considered for this position until all required assessments have been completed.

Applicants considered for this position will be required to disclose if they are the subject of any substantiated findings or current investigations related to sexual misconduct at their current employment and past employment. Disclosure is required under Washington state law.

CLICK HERE TO APPLY