Employment

Research Scientist 1 – Translational

In this position, you will support the IPD’s Translational Program. Research activities will involve the execution and analysis of standard protein expression, purification and biophysical characterization methods and data, with eventual independent operation thereof. You will also help manage, maintain and upkeep the Translational IPD laboratories.

RESPONSIBILITIES:

In this role, ~80% of effort will be dedicated to the production, optimization and formulation of designed proteins. Bacterial and mammalian protein production will involve interaction with standing IPD Core facilities and staff.

Once expertise is gained, the remaining ~20% of effort will be dedicated to quality control of designed proteins using biophysical and biochemical characterization techniques.

MINIMUM REQUIREMENTS
Bachelor’s Degree in Biochemistry or related field plus 3 months or more experience in related areas.

Additional Requirements:
• Candidates must be capable of applying standardized scientific procedures and techniques to assignments of limited complexity, involving potentially conflicting design requirements.
• Familiarity with office productivity software (Word, PowerPoint, Excel) to prepare research reports on the work performed.
• Strong and clear communication skills in English, both oral written.
• Ability to work with little supervision, through initiative and good judgment.

Equivalent education and/or experience may substitute for minimum requirements.

DESIRED REQUIREMENTS
An ideal Research Scientist 1 candidate will be someone who (i) has had experience in a laboratory setting during the undergraduate degree obtention, (ii) will use their knowledge gained in their undergraduate degree program to apply fundamental concepts, practices and procedures, (iii) follows procedures for small projects and/or major project tasks which may last years under immediate supervision, and effectively manages them under guidance and direction from project staff; interfaces with investigator peers, (iv) can provide timely and professional scientific services to a number of internal collaborators on approximately 2-3 different projects, (v) can perform tasks and methods as directed, (vi) and enjoys interacting with other scientists in a highly collaborative and fast-paced work environment.

CONDITIONS OF EMPLOYMENT
• The position requires the ability to transport equipment along footpaths between multiple sites, and to lift equipment to/from a rolling cart.

Application Process:
The application process for UW positions may include completion of a variety of online assessments to obtain additional information that will be used in the evaluation process. These assessments may include Work Authorization, Cover Letter and/or others. Any assessments that you need to complete will appear on your screen as soon as you select “Apply to this position”. Once you begin an assessment, it must be completed at that time; if you do not complete the assessment you will be prompted to do so the next time you access your “My Jobs” page. If you select to take it later, it will appear on your “My Jobs” page to take when you are ready. Please note that your application will not be reviewed, and you will not be considered for this position until all required assessments have been completed.

Committed to attracting and retaining a diverse staff, the University of Washington will honor your experiences, perspectives and unique identity. Together, our community strives to create and maintain working and learning environments that are inclusive, equitable and welcoming.

CLICK HERE TO APPLY

Research Scientist 2 – MLS

RESPONSIBILITIES:
The primary responsibilities of the RES2-MLS are:
• Construction of gene libraries from chip synthesized oligonucleotides and screening of computationally designed minibinders with functional features using fluorescence-activated cell sorting (FACS), next-generation DNA sequencing, followed by clonal protein production and biophysical testing of function.
• Regularly review, analyze, and troubleshoot all experimental results for all minibinder molecular library production from chip synthesized oligonucleotides including fragment amplification, plasmid verification, sequencing data quality assessment, yeast strain verification, and flow cytometry.
• Design, test, and implement protocols and techniques into existing minibinder molecular library construction and screening workflows to improve standardization and efficiency.
• Collaborate with other research staff, postdoctoral fellows and graduate students on computational minibinder protein screening, production and characterization.
• Evaluate current and proposed protocols for accuracy, reagent conservation, and validity of resulting data.
• Works effectively as a member of a team under technical guidance of seasoned staff; establishes productive relationships with co-workers, customers and others to accomplish team objectives; may guide the work of co-workers, students, research aides/assistants, technicians or other support staff as necessary to achieve specific assignments.
• Leads small projects and/or major project tasks which may last years, and effectively manages them by providing guidance and direction to project staff; makes substantial contributions to determining feasibility of goals/objectives; interfaces with investigator peers.
• Performs assignments designed to develop professional work knowledge providing foundation for innovative thinking and techniques
• Works under immediate supervision to complete assigned tasks/projects.
In this role, the RES2 – MLS will spend ~60% of the effort dedicated to the molecular library construction screening activities.
A ~20% of effort will be dedicated to the maintenance of instruments needed for molecular screening.
The remaining ~20% of effort will be dedicated to protein production and biophysical characterization of single proteins.

REQUIREMENTS:
• Bachelor’s Degree in Biochemistry, Biology or related field + 2 years or more of experience in a related field.
• The Research Scientist 2 – MLS is devoted primarily to scientific research and requires a B. Sc. in a Biochemistry, biology-related field. Experience with molecular library construction, FACS machines and next-generation DNA sequencing desired. Candidates must be capable of selecting and applying standardized scientific procedures and techniques to assignments of moderate complexity, involving potentially conflicting design requirements.

Equivalent education/experience will substitute for all minimum qualifications except when there are legal requirements, such as a license/certification/registration.

DESIRED EXPERIENCE
• Technical proficiency, scientific creativity, collaborative ability as well as independent thought.
•          Recognized as a resource for others to use in dealing with molecular library screening. Anticipates future needs in novel protocol development.
•          Ability to develop innovative processes to achieve goals. Reviews work activities to determine where new information could improve processes or move projects forward.
• Ability to select and apply standardized scientific procedures and techniques to assignments of moderate complexity, involving potentially conflicting assay requirements.

As a UW employee, you will enjoy generous benefits and work/life programs.  For detailed information on Benefits for this position, click here.

Application Process:
The application process for UW positions may include completion of a variety of online assessments to obtain additional information that will be used in the evaluation process.  These assessments may include Workforce Authorization, Cover Letter and/or others.  Any assessments that you need to complete will appear on your screen as soon as you select “Apply to this position”. Once you begin an assessment, it must be completed at that time; if you do not complete the assessment you will be prompted to do so the next time you access your “My Jobs” page. If you select to take it later, it will appear on your “My Jobs” page to take when you are ready. Please note that your application will not be reviewed, and you will not be considered for this position until all required assessments have been completed.

Applicants considered for this position will be required to disclose if they are the subject of any substantiated findings or current investigations related to sexual misconduct at their current employment and past employment. Disclosure is required under Washington state law.

Committed to attracting and retaining a diverse staff, the University of Washington will honor your experiences, perspectives and unique identity. Together, our community strives to create and maintain working and learning environments that are inclusive, equitable and welcoming.

CLICK HERE TO APPLY

Research Scientist Assistant – MLS

The Research Scientist Assistant – MLS  will be assigned work under general guidance and receive instruction on specific assignment objectives, complex features, and possible solutions. Guidance on unusual problems will be provided to the Research Scientist Assistant – MLS by IPD Faculty, senior scientists, and postdoctoral scholars other UW Faculty, or other experts and work shall be reviewed for application of sound professional judgment.

RESPONSIBILITIES:
The Research Scientist Assistant MLS  will interface directly with members of the Baker lab, other IPD Core Laboratories as well as graduate students and postdoctoral scholars at the IPD. The research activities will involve molecular library screening, with eventual independent operation thereof.  The RS Assistant- MLS will also assist in  the production and testing of proteins.

In this role, ~60% of the effort will be dedicated to the molecular screening activities.

A ~20% of effort will be dedicated to maintenance of instruments needed for molecular screening.

The remaining ~20% of effort will be dedicated  to protein production and biophysical characterization of single proteins.

REQUIREMENTS:
• Bachelor’s Degree in Biochemistry, Biology or similar + less than 3 months of experience in related field.
• The Research Scientist Assistant MLS is devoted primarily to scientific research and requires a B. Sc. in a biology-related field.
• Candidates must be capable of selecting and applying standardized scientific procedures and techniques to assignments of moderate complexity, involving potentially conflicting design requirements.

Equivalent education/experience will substitute for all minimum qualifications except when there are legal requirements, such as a license/certification/registration.

DESIRED EXPERIENCE
• Experience with mammalian cell analysis techniques, including western blotting and flow cytometry, is preferred.
• Experience with FACS machines and next-generation DNA sequencing desired.
• An ideal Research Scientist Assistant – MLS candidate will be someone who (i) has had experience in a laboratory setting during the undergraduate degree obtention, (ii) will use their knowledge gained in their undergraduate degree program to apply fundamental concepts, practices and procedures, (iii) follows procedures for small projects and/or major project tasks which may last years under immediate supervision, and effectively manages them under guidance and direction from project staff; interfaces with investigator peers, (iv) can provide timely and professional scientific services to a number of internal collaborators on approximately 2-3 different projects, (v) can perform tasks and methods as directed, (vi) and enjoys interacting with other scientists in a highly collaborative and fast-paced work environment.

Application Process:
The application process for UW positions may include completion of a variety of online assessments to obtain additional information that will be used in the evaluation process.  These assessments may include Workforce Authorization, Cover Letter and/or others.  Any assessments that you need to complete will appear on your screen as soon as you select “Apply to this position”. Once you begin an assessment, it must be completed at that time; if you do not complete the assessment you will be prompted to do so the next time you access your “My Jobs” page. If you select to take it later, it will appear on your “My Jobs” page to take when you are ready. Please note that your application will not be reviewed, and you will not be considered for this position until all required assessments have been completed.

Applicants considered for this position will be required to disclose if they are the subject of any substantiated findings or current investigations related to sexual misconduct at their current employment and past employment. Disclosure is required under Washington state law.

Committed to attracting and retaining a diverse staff, the University of Washington will honor your experiences, perspectives and unique identity. Together, our community strives to create and maintain working and learning environments that are inclusive, equitable and welcoming.

CLICK HERE TO APPLY

Research Scientist 3 – Nanoparticles

The Research Scientist 3 – Nanoparticle Production Core will perform professional work in support of scientific research in protein production and biophysical characterization of computationally designed proteins. The research activities involve leading production of nanoparticle vaccine candidates and nanoparticle components at the IPD.

RESPONSIBILITIES:
In this role, 80% of effort will be dedicated to the production and management of ongoing nanoparticle projects. The remaining 20% of the effort will be dedicated to training and mentoring of direct and indirect reports.

1. Collaboration with numerous researchers at the IPD in the production of designed self-assembling protein nanoparticles and their components, including preparation of detailed Certificates of Testing and/or reports.

2. Participates in complex projects with uncertain outcomes requiring analysis from multiple perspectives.

3. Uses expert knowledge and judgment to develop new methods and techniques for obtaining solutions EM characterization of de novo designed proteins and protein nanomaterials. 

4. Manage the activities of two (2) entry-level technical support staff along with a minimum of one (1) part-time undergraduate support person.

5. Directs projects with undefined timelines and uncertain outcomes requiring analysis from multiple perspectives.

6. Uses expert knowledge and judgment to develop new methods and techniques for obtaining solutions.

REQUIREMENTS:
Bachelor’s degree in Protein Biochemistry or Bioengineering + 3 or more years of experience in a related field to include: experience in protein expression, purification, and characterization; and experience in hands nanoparticle production and characterization.
• This position requires that the Research Scientist 3 be capable of selecting and applying standardized scientific procedures and techniques to assignments of moderate complexity, involving potentially conflicting design requirements.
• Technical proficiency, scientific creativity, collaborative ability as well as independent thought.
• Recognized as a resource for others to use in dealing with protein expression, purification, and characterization.
• In-depth understanding of organizational structure both within and outside the work unit, including the role of each position in the group and in other groups.
• Ability to develop innovative processes to achieve goals. Directs others to develop essential tasks. Reviews work activities to determine where new information could improve processes or move projects forward.
• Ability to select and apply standardized scientific procedures and techniques to assignments of moderate complexity, involving potentially conflicting design requirements.

Equivalent education/experience will substitute for all minimum qualifications except when there are legal requirements, such as a license/certification/registration.

DESIRED EXPERIENCE
The ideal Research Scientist 3 in Nanoparticle Production Core will be someone who (i) selects and applies standardized scientific procedures and techniques to assignments of moderate complexity, (ii) continually learns and develops methods, (iii) can manage individual research projects that they own, (iv) knows or can learn how to operate current purification and characterization instruments at the IPD, (v) can accurately process negative stain EM imaging data, (vi) and has a deep desire to train others as a mentor in all of these areas, so that others within the IPD can successfully manufacture nanoparticles following efficient standard operating procedures.
• Expertise in protein structural characterization by negative stain EM methods.
• Expertise in computational protein design using Rosetta
• Familiarity in vaccine efficacy study design, in order to contribute to the design of immunogenicity and
efficacy studies for vaccine candidates.
• Familiarity with GLP practices, including Certificates of Testing and batch records.

Application Process:
The application process for UW positions may include completion of a variety of online assessments to obtain additional information that will be used in the evaluation process.  These assessments may include Workforce Authorization, Cover Letter and/or others.  Any assessments that you need to complete will appear on your screen as soon as you select “Apply to this position”. Once you begin an assessment, it must be completed at that time; if you do not complete the assessment you will be prompted to do so the next time you access your “My Jobs” page. If you select to take it later, it will appear on your “My Jobs” page to take when you are ready. Please note that your application will not be reviewed, and you will not be considered for this position until all required assessments have been completed.

Applicants considered for this position will be required to disclose if they are the subject of any substantiated findings or current investigations related to sexual misconduct at their current employment and past employment. Disclosure is required under Washington state law.

Committed to attracting and retaining a diverse staff, the University of Washington will honor your experiences, perspectives and unique identity. Together, our community strives to create and maintain working and learning environments that are inclusive, equitable and welcoming.

CLICK HERE TO APPLY

Research Scientist 1 – Protein Production

The UW Institute for Protein Design is seeking to hire a Research Scientist I whose duties will be to provide experimental support for research projects as part of the IPD Protein Production Facility. The Research Scientist/Engineer will be part of a small team focused on the expression, purification, and characterization of proteins for both internal investigators as well as external collaborators. 

Main duties will include protein expression, purification, and characterization. Additional tasks will include helping with general lab support as needed under supervision.   Experience in quality assurance, mass spectrometry, and other biophysical characterization techniques is optional.

Candidate must have familiarity with office productivity software (Word, Powerpoint, Excel) to prepare research reports for on the work performed.  Candidate must be proficient with sterile laboratory maintenance, and familiar with BSL1 requirements. Candidate will assist graduate students, post-doctoral fellows, and research staff with protein expression, purification, and biophysical characterization, and using established experimental protocols.

This position will facilitate the work of the Institute for Protein Design (IPD), adding capabilities to produce our designed proteins in mammalian cell culture, within the Department of Biochemistry and the UW School of Medicine.

RESPONSIBILITIES:
• Expression of recombinant proteins in E. coli
• Chromatographic protein purification (e.g. IMAC and SEC)
• Protein Characterization and analytics (e.g. SDS-PAGE, SECMALS, mass spec)
• Quality Assurance tasks – document review, SOP creation and revision, etc.
• Carry out established experimental protocols like plasmid preparation and extraction, PCR, transformations, protein expression, and protein purification, under limited supervision.
• Perform technical procedures such as gel electrophoresis, chromatography, and mass spectrometry
• Maintain bacterial cultures
• Willingness to learn new techniques
• Keep a detailed and organized electronic lab notebook
• Participate in laboratory meetings and planning sessions
• Prepare laboratory reagents
• Service and maintain laboratory instruments as needed
• Work well under limited supervision
• May demonstrate and explain various laboratory techniques to laboratory personnel, students, and others
• Perform related duties as required
• May demonstrate and explain various laboratory techniques to laboratory personnel, students, and others
• Perform related duties as required

REQUIREMENTS:
• Bachelor’s Degree in Molecular Biology/Biochemistry/Cell Biology or related Life Sciences.
• One year or less of experience with the following:
• Experience in the expression of recombinant proteins in E. coli, and purification using affinity chromatography.  The ideal candidate should have experience in the expression, purification, and characterization of recombinant proteins.
• The position requires the ability to transport equipment along footpaths between multiple sites, and to lift equipment (~35lb) to/from a rolling cart. The IPD has facilities in two locations on campus, 0.4 mi apart.
• Experience with Windows and Mac operating systems and general computer use.
• Strong and clear communication skills in English, both oral written, are required.
• Ability to work with little supervision, through initiative and good judgment.
• The position will be in a collaborative research environment with multiple stakeholders that will interact with this position 

Equivalent education/experience will substitute for all minimum qualifications except when there are legal requirements, such as a license/certification/registration.

DESIRED EXPERIENCE
• Experience in Quality Assurance – document review and control, etc.
• Experience working in BSL1-2 research facilities
• Experience producing recombinant proteins in microbial systems.
• Experience in the purification of recombinant proteins using affinity and size exclusion chromatography.

Application Process:
The application process for UW positions may include the completion of a variety of online assessments to obtain additional information that will be used in the evaluation process.  These assessments may include Workforce Authorization, Cover Letter and/or others.  Any assessments that you need to complete will appear on your screen as soon as you select “Apply to this position”. Once you begin an assessment, it must be completed at that time; if you do not complete the assessment you will be prompted to do so the next time you access your “My Jobs” page. If you select to take it later, it will appear on your “My Jobs” page to take when you are ready. Please note that your application will not be reviewed, and you will not be considered for this position until all required assessments have been completed.

Applicants considered for this position will be required to disclose if they are the subject of any substantiated findings or current investigations related to sexual misconduct at their current employment and past employment. Disclosure is required under Washington state law.

Committed to attracting and retaining a diverse staff, the University of Washington will honor your experiences, perspectives and unique identity. Together, our community strives to create and maintain working and learning environments that are inclusive, equitable and welcoming.

CLICK HERE TO APPLY

Preclinical Research Scientist 3

The UW Institute for Protein Design is seeking to hire a Preclinical Research Scientist (Research Scientist/Engineer 3) to serve as the leader for in vivo small animal studies. This Preclinical Research Scientist will provide a core competency in in vivo animal models at the IPD, thereby fulfilling a growing demand for the evaluation of the functional characteristics of designed proteins in vivo. The Preclinical Research Scientist will be assigned work under general guidance and receive instruction on specific assignment objectives, complex features, and possible solutions. Guidance on unusual problems will be provided to the Preclinical Research Scientist by IPD Faculty, other UW Faculty, or animal facilities employees who are experts in animal models, and work shall be reviewed for application of sound professional judgment.

The Preclinical Research Scientist will serve as the lead scientist in the IPD’s In Vivo Core lab, having oversight of collaborative preclinical in vivo research using small animal models to assess biodistribution, pharmacokinetics, safety, efficacy, and immunogenicity of computationally designed proteins and immunogens. This position will perform professional work in support of scientific research evaluating the characteristics of designed proteins in vivo in common small animal models.

RESPONSIBILITIES:
• In this role, ~60% of the effort will be dedicated to performing preclinical research evaluating the characteristics of designed proteins in vivo in common small animal models.
• Another ~30% of effort will be dedicated to coordinating study designs and communicating the results and interpretations of each study with a number of internal collaborators at the IPD and in some cases external collaborators at other institutions.
• The remaining ~10% of effort will be dedicated to continuous improvement of the In Vivo Core lab operations and standard operating procedures and interfacing with UW veterinary service personnel and the Office of Animal Welfare (OAW).

REQUIREMENTS:
• Master’s Degree in Biochemistry + 3 or more years of experience in related field.
• The ideal Preclinical Research Scientist candidate will be someone who (i) selects and applies standardized scientific procedures and techniques to assignments of moderate to high complexity, involving potentially conflicting design requirements, (ii) continually learns and develops new in vivo methods and study designs, (iii) can manage individual research projects that they own, (iv) can provide timely and professional scientific services to a number of internal collaborators on several different projects, (v) can perform in vivo studies of novel molecules in a safe and humane manner, (vi) and enjoys interacting with other scientists in a highly collaborative and fast-paced work environment.

Equivalent education/experience will substitute for all minimum qualifications except when there are legal requirements, such as a license/certification/registration.

DESIRED EXPERIENCE
• Excellent knowledge of small animal biology and immunology and experience in conducting exploratory research using xenograft or syngeneic tumor models and humanized mouse models is highly preferred.
• Significant hands-on experience with mouse and rat models and their application in evaluating anti-cancer therapies, immunotherapeutics, or vaccines is highly desired.
• Experience with immunological readouts and their translation into early clinical trials is highly desirable.
• Familiarity with drug discovery is a plus.
• The ability to flourish in a highly matrixed organization and work well within multidisciplinary teams is desirable.

As a UW employee, you will enjoy generous benefits and work/life programs. For detailed information on Benefits for this position, click here.

Application Process:
The application process for UW positions may include completion of a variety of online assessments to obtain additional information that will be used in the evaluation process.  These assessments may include Workforce Authorization, Cover Letter and/or others.  Any assessments that you need to complete will appear on your screen as soon as you select “Apply to this position”. Once you begin an assessment, it must be completed at that time; if you do not complete the assessment you will be prompted to do so the next time you access your “My Jobs” page. If you select to take it later, it will appear on your “My Jobs” page to take when you are ready. Please note that your application will not be reviewed, and you will not be considered for this position until all required assessments have been completed.

Applicants considered for this position will be required to disclose if they are the subject of any substantiated findings or current investigations related to sexual misconduct at their current employment and past employment. Disclosure is required under Washington state law.

CLICK HERE TO APPLY