Employment

We are looking for talented individuals to join our growing team. If you enjoy working in or wish to support a dynamic research environment, contact us to learn more about potential job opportunities.

Research Scientist Engineer 1 — Foldit Developer

Opening: Current

As a UW employee, you have a unique opportunity to change lives on our campuses, in our state and around the world. UW employees offer their boundless energy, creative problem solving skills and dedication to build stronger minds and a healthier world.

UW faculty and staff also enjoy outstanding benefits, professional growth opportunities and unique resources in an environment noted for diversity, intellectual excitement, artistic pursuits and natural beauty. All of which has allowed the UW to be nationally recognized as a “Great College to Work For” for four consecutive years.

The Department of Biochemistry at the University of Washington has contributed to many phases of research. Initially recognized for incisive studies of the structure and function of proteins, and the mechanisms of enzyme action, the department branched out into a multitude of other areas. These included: developmental biology of flies, fish, frogs, and mice; molecular mechanisms of aging in yeast and mammals; vertebrate visual and immune responses; chromosome dynamics, cell division, DNA replication and repair; energy transduction during photosynthesis; protein secretion and membrane fusion; translational control and regulated protein degradation; protein structure determination by crystallography and NMR spectroscopy; and protein structure prediction and enzyme design. Our diversity of interests guarantees a rich intellectual and educational environment.

About the Institute for Protein Design:
The Institute for Protein Design (IPD) at the University of Washington in Seattle is creating a new world of synthetic proteins to address 21st-century challenges in medicine, energy, and technology. The IPD is a unique interdisciplinary environment where world-class researchers with expertise in computing and software, biochemistry, genome sciences, biological structure, pharmacology, immunology and other basic science disciplines, as well as clinical medicine, work together to both computationally design and experimentally characterize novel biomolecules. Current projects include the design of novel therapeutics for cancer, neurological diseases, and more, as well as new vaccines, nanomaterials, and enzymes.

The Department of Biochemistry currently has an outstanding opportunity for a Research Engineer 1/Foldit Software Developer.

The specific field of research for this Research Engineer 1 / Foldit Software Developer is in the development of the protein folding game Foldit, which is used to crowdsource real biochemistry problems to game players. For more detailed information about the Institute for Protein Design please see http://www.ipd.uw.edu/.

The Research Engineer 1 / Foldit Software Developer position will coordinate with the interdisciplinary Foldit team to implement, refine, test, and deploy features for the game. The position will develop in-game tools, visualizations, game mechanics and rewards, with an emphasis on support for synthetic protein design.

    • Develop new software features for the Foldit game, and maintain the Foldit source code.
    • Communicate with Foldit community to solicit and address feedback from game players.
    • Collaborate with other research staff, postdoctoral fellows and graduate students on computational de novo protein design.
    • Participate in projects with uncertain outcomes requiring analysis from multiple perspectives.
    • Use expert knowledge and judgment to develop new methods and tools for de novo protein design challenges.

Minimum Requirements:

    • B.S. in computer science or equivalent experience in a programming/software engineering field + 3 months or more years of experience in related field.
    • Proficiency in C++
    • Experience with version control (preferably git)
    • Works well independently and in teams
    • Self-motivated with great organization, communication, and problem-solving skills

Desired Requirements:

  • Python development
  • Network development
  • Cross-platform (Windows/macOS/Linux) development
  • Experience in computational protein design with Rosetta molecular design and modeling algorithms.

Please apply online at UWHires. Do not reach out to the department or employees directly. The direct link is:

https://uwhires.admin.washington.edu/eng/candidates/default.cfm?szCategory=jobprofile&szOrderID=168330

Software Engineer — Machine Learning

Opening: Current

The UW Institute for Protein Design currently has an outstanding opportunity for a full-time SOFTWARE ENGINEER with expertise in machine learning. The Institute for Protein Design is designing a new world of synthetic proteins for 21st-century challenges.
PRIMARY RESPONSIBILITIES

Perform software engineering of specific Rosetta code for use in relation to GPGPU accelerated computing for reinforcement learning for conformational search for protein structure prediction and design.

  • Develop GPGPU accelerated code for specific Rosetta subroutines for protein structure prediction and design.
  • In collaboration with researchers at the Institute for Protein Design, develop deep learning and reinforcement learning approaches for protein conformational sampling, de novo design of new proteins,  protein structure refinement, and design of high-affinity binding proteins.
  • Collaborate with the Investigator and numerous researchers at the Institute for Protein Design on SOFTWARE ENGINEERing of specific Rosetta code for use in relation to GPGPU accelerated computing for conformational sampling for de novo design of new proteins,  protein structure refinement, and design of high-affinity binding proteins.
  • Collaborates with other research staff, postdoctoral fellows and graduate students on de novo design of new proteins.
  • Trains others in how to use Rosetta SOFTWARE, deep learning, and protein design computing infrastructure.
MINIMUM QUALIFICATIONS:
Doctoral Degree in Computational Protein Design or related programming/software engineering field and 2 or more years of related experience.
DESIRED QUALIFICATIONS:
  • Experience in Computational protein design with Rosetta, Software languages and database architectures.
  • Familiarity with machine learning strategies and energy function optimization.
  • Equivalent education/experience will substitute for all minimum qualifications except when there are legal requirements, such as a license/certification/registration.

Please apply online at UWHires. Do not reach out to the department or employees directly. The direct link is:

http://uwhires.admin.washington.edu/ENG/candidates/default.cfm?szCategory=jobprofile&szOrderID=163347&szCandidateID=0&szSearchWords=&szReturnToSearch=1

Research Scientist 1 — Computer Science

Opening: Current

The UW Institute for Protein Design fcurrently has an outstanding opportunity for a Research Engineer 1  in Computer Science. This position will design improved algorithms for computational protein design, with special emphasis on machine learning approaches in the optimization of de novo protein design protocols.

PRIMARY RESPONSIBILITIES
  • Collaborate with the Investigator and numerous researchers at the Institute for Protein Design on de novo design of new proteins.
  • Collaborates with other research staff, postdoctoral fellows and graduate students to on de novo design of new proteins.
  • Manages complex multi-task projects directed at the design, production, and characterization of numerous de novo designed proteins with higher order function.
  • Trains others in how to use Rosetta software and protein design computing infrastructure.
  • Participates in complex projects with uncertain outcomes requiring analysis from multiple perspectives. 
  • Use expert knowledge and judgment to develop new methods and techniques for obtaining solutions to de novo protein design challenges.
MINIMUM QUALIFICATIONS:
  • Bachelor’s Degree in Computer Science or Electrical Engineering + 3 months or more years of experience in related field or equivalent experience in a programming/software engineering field.
  • At least two quarters of graduate student/PhD program level studies in computer science, machine learning, and protein biochemistry including wet lab experience.
  • Proficiency with office productivity software (e.g. Google apps, Word, Powerpoint, Excel) to prepare research reports.  
  • At least one year of wet lab related protein research experience with molecular DNA cloning and protein production, purification, and biophysical characterization in a biochemistry research laboratory.
DESIRED QUALIFICATIONS:
  • Experience in Computational protein design with Rosetta, Software languages and database architectures.
  • Familiarity with machine learning strategies and energy function optimization.
  • Equivalent education/experience will substitute for all minimum qualifications except when there are legal requirements, such as a license/certification/registration.

Please apply online at UWHires. Do not reach out to the department or employees directly. The direct link is:

https://uwhires.admin.washington.edu/eng/candidates/default.cfm?szCategory=jobprofile&szOrderID=165132&szCandidateID=0&szSearchWords=&szReturnToSearch=1

Research Scientist / Engineer 1 — Cell Signaling 

Opening: Pending

The UW Institute for Protein Design is seeking to hire a Research Scientist 1 whose duties will be to provide experimental support for research projects as part of the IPD Protein Production Facility, Mammalian Core.  The Research Scientist/Engineer will be part of a small team focused on cell based assays.

In this role, ~60% of the effort will be dedicated to the culture and maintenance of a variety of mammalian cell lines.  

Another ~10% of effort will be dedicated to support the production of proteins secreted from mammalian cell culture. 

The remaining ~30% of effort will be dedicated  to signaling and other cell-based assays.  

MINIMUM REQUIREMENTS
  • Bachelor’s Degree in Molecular Biology, Biochemistry, Cell Biology, or related field.
  • +1 years work experience with tissue culture.

Please apply online at UWHires. Do not reach out to the department or employees directly. The direct link will be provided soon.

Undergraduate Administrative Assistant

Opening: Current

 
PRIMARY RESPONSIBILITIES
  • Provide complex executive assistant support including calendaring for IPD management.
  • Coordinate letters of support/recommendation following detailed instructions, based on existing templates, using a variety of web forms, working under the guidance from IPD management.
  • Other activities as needed to support the smooth functioning of day-to-day administrative activities at the IPD.

Please apply online at Handshake. Do not reach out to the department or employees directly. The direct link is:

https://app.joinhandshake.com/jobs/2803536

Research Scientist Engineer Assistant – NPC

Opening: Current

 
PRIMARY RESPONSIBILITIES

The Research Scientist Assistant – NPC will support the Nanoparticle Production Core.  The research activities will involve the execution and analysis of standard protein expression, purification and biophysical characterization methods and data, with eventual independent operation thereof.  The RSA NPC will also assist in the optimization of methods listed above for novel designed proteins. 

In this role, ~40% of the effort will be dedicated to the maintenance of protein nanoparticle component stocks for use by IPD Faculty laboratories and by the Nanoparticle Production Core. 

Another ~20% of effort will be dedicated to assembly and quality control of the protein nanoparticles.  

The remaining ~40% of effort will, eventually, be dedicated to the production and quality control of functionalized nanoparticles, such as those for vaccine and drug delivery development, once expertise is gained. 

Minimum Requirements: 

  • Bachelor’s Degree in Biochemistry, Biology or similar + less than 3 months of experience in related field. 
  • The Research Scientist Assistant-NPC is devoted primarily to scientific research and requires a B. Sc. in a biology-related field,  with <3 months of experience in expression and purification of protein. Candidates must be capable of applying standardized scientific procedures and techniques to assignments of limited complexity, involving potentially conflicting design requirements. 

Please apply online at Handshake. Do not reach out to the department or employees directly. The direct link is:

https://uwhires.admin.washington.edu/ENG/Candidates/default.cfm?szCategory=jobprofile&szOrderID=173086

Research Scientist Assistant – Translational

Opening: Current

 
PRIMARY RESPONSIBILITIES

The specific field of research for this Research Scientist Assistant – TPE is in protein production and biophysical characterization using bacterial and mammalian expression systems, chromatography techniques (mainly immobilized metal affinity and size exclusion chromatography), SDS-PAGE, Western blotting, dynamic light scattering, fluorescence microscopy, and UV-Vis spectrophotometry.

The UW Institute for Protein Design is seeking to hire a Research Scientist Assistant – TPE to support the development of designed proteins for pre-clinical assays at the Institute for Protein Design (IPD). The Research Scientist Assistant – TPE will be assigned work under close guidance and receive explicit instruction on specific assignment objectives, complex features, and possible solutions. Guidance on unusual problems will be provided to the Research Scientist Assistant – TPE by IPD Faculty, other UW Faculty, or other experts in protein production and biophysical characterization and work shall be reviewed for application of sound professional judgment.

The Research Scientist Assistant – TPE will support the IPD’s Translational Program. The research activities will involve the execution and analysis of standard protein expression, purification and biophysical characterization methods and data, with eventual independent operation thereof. The RSA TPE will also help manage, maintain and upkeep the Translational IPD laboratories.

In this role, ~40% of the effort will be dedicated to production, optimization and formulation of designed proteins. Bacterial and mammalian protein production will involve interaction with standing IPD Core facilities and staff.

Another ~30% of the effort will be dedicated to management, maintenance and upkeep of the Translational IPD laboratories. Tasks include: ordering consumables, maintaining reagent stocks, organization, cleanliness and adherence to EH&S safety standards.

Once expertise is gained, the remaining ~30% of effort will be dedicated to quality control of designed proteins using biophysical and biochemical characterization techniques.

Minimum Requirements: 

    • Bachelor’s Degree in Biochemistry, Biology or similar + less than 3 months of experience in related field

Additional Requirements: 

  • Experience in expression and purification of protein.
  • Candidates must be capable of applying standardized scientific procedures and techniques to assignments of limited complexity, involving potentially conflicting design requirements

An ideal Research Scientist Assistant – TPE candidate will be someone who (i) has had experience in a laboratory setting during the undergraduate degree obtention, (ii) will use their knowledge gained in their undergraduate degree program to apply fundamental concepts, practices and procedures, (iii) follows procedures for small projects and/or major project tasks which may last years under immediate supervision, and effectively manages them under guidance and direction from project staff; interfaces with investigator peers, (iv) can provide timely and professional scientific services to a number of internal collaborators on approximately 2-3 different projects, (v) can perform tasks and methods as directed, (vi) and enjoys interacting with other scientists in a highly collaborative and fast-paced work environment.

Equivalent education/experience will substitute for all minimum qualifications except when there are legal requirements, such as a license/certification/registration.

Please apply online at Handshake. Do not reach out to the department or employees directly. The direct link is:

https://uwhires.admin.washington.edu/ENG/Candidates/default.cfm?szCategory=jobprofile&szOrderID=174030

Research Scientist Assistant – Mammalian Expression

Opening: Current

 
PRIMARY RESPONSIBILITIES

The UW Institute for Protein Design currently has an outstanding opportunity for a Research Scientist Assistant – MPC to serve as part of the Mammalian Production Core at the Institute for Protein Design (IPD). The Research Scientist Assistant – MPC will be assigned work under close guidance and receive explicit instruction on specific assignment objectives, complex features, and possible solutions. Guidance on unusual problems will be provided to the Research Scientist Assistant – MPC by IPD Faculty, other UW Faculty, or other experts in protein production and biophysical characterization and work shall be reviewed for application of sound professional judgment.

The specific field of research for this Research Scientist Assistant – MPC is in protein production and purification using mammalian expression systems, chromatography techniques (mainly immobilized metal affinity and size exclusion chromatography), SDS-PAGE, and UV-Vis spectrophotometry.

he Research Scientist Assistant – MPC will support the Mammalian Production Core. The research activities will involve the execution and analysis of standard protein expression, purification and biophysical characterization methods and data, with eventual independent operation thereof. The RSA MPC will also assist in the optimization of methods listed above for novel designed proteins.

In this role, ~20% of the effort will be dedicated to the production of plasmid DNA for transient transfection.

Another ~20% of effort will be dedicated to maintenance of BLS2 space and upkeep of cell lines.

Another ~20% of effort will be dedicated to production of protein in mammalian expression systems

The remaining ~40% of effort will be dedicated to the purification of proteins using IMAC and SEC chromatography and the determination of quality control aspects of purified proteins using techniques such as SDS_PAGE, UV-Vis, endotoxin testing, and SEC-MALS.

Minimum Requirements: 

    • Bachelor’s Degree in Biochemistry, Biology, or similar + less than 3 months of experience in related field
    • The Research Scientist Assistant-MPC is devoted primarily to scientific research and requires a B. Sc. in a biology-related field, with <3 months experience in expression and purification of protein. Candidates must be capable of applying standardized scientific procedures and techniques to assignments of limited complexity, involving potentially conflicting design requirements .

An ideal Research Scientist Assistant – MPC candidate will be someone who (i) has had experience in a laboratory setting during the undergraduate degree (ii) will use their knowledge gained in their undergraduate degree program to apply fundamental concepts, practices and procedures, (iii) follows

procedures for small projects and/or major project tasks which may last years under immediate supervision, and effectively manages them under guidance and direction from project staff; interfaces with investigator peers, (iv) can provide timely and professional scientific services to a number of internal collaborators on approximately 2-3 different projects, (v) can perform tasks and methods as directed, (vi) and enjoys interacting with other scientists in a highly collaborative and fast-paced work environment.

Equivalent education/experience will substitute for all minimum qualifications except when there are legal requirements, such as a license/certification/registration.

Please apply online at Handshake. Do not reach out to the department or employees directly. The direct link is:

https://uwhires.admin.washington.edu/ENG/Candidates/default.cfm?szCategory=jobprofile&szOrderID=173712